It is the third most diagnosed cancer among men and women in the United States. Rates of colorectal cancer have declined over the past few decades. This is largely because more people are getting routine colorectal cancer screenings. During some of these screening tests, like colonoscopies, doctors can remove polyps before they become cancer. Generally, the risk of colorectal cancer increases with age. However, cases of colorectal cancer have Ventoxen 100mg (Venetoclax) steadily been increasing among adults younger than 50 in the United States and in other countries, including Canada, New Zealand, and Australia. In 2021, the U.S. Preventive Services Task Force updated its guidelines to recommend that people at average risk for colorectal cancer start screening at age 45. Previously, the recommended age to start screening was 50. Read More About Colorectal Cancer Screening Guidelines At this time, little is known about the reasons for the increase in early-onset colorectal cancer.
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So, it is not clear if and how obesity may be associated with the increase. However, obesity is a known risk factor for colorectal cancer. How Are Obesity & Colorectal Cancer Linked? There are several possible reasons why obesity may increase the risk for colorectal cancer. Researchers have been exploring the potential connections. Studies include the ways obesity can impact the function of essential hormones and other processes in the body. Possible connections include: Chronic inflammation: Excess fat can create a low-oxygen environment, leading to inflammation, which can increase people’s risk of cancer.1 Obesity-related inflammation has been linked to colorectal carcinogenesis (when normal cells become cancer cells).2 However, more research is needed to identify specific factors that may connect inflammation and cancer, including colorectal cancer.